To measure the temperature at the nanoscale it has always been a challenging part for the researchers especially on living organisms as there were no proper nanothermometers present.
As published in the research a team from Osaka City University, in collaboration with other international partners, has presented a stable, decisive microscopic thermometer with the help of quantum technology which measures the temperature in microscopic animals. It calculates the temperature-dependent properties of quantum spins in fluorescent nanodiamonds.
In biology, an optical microscope is generally used for the study along with the help of visible light to recognize microscopic formation. Although in the modern lab’s researchers use a fluorescence microscope, which is a developed version of an optical microscope made up using the fluorescent biomarkers. It helps in live imaging of the details in a microscopic structure and it also grants researchers to gain various physiological parameters like pH level, reactive oxygen species, and temperature.
To measure the physical quantity the technology used is Quantum sensing that uses the quantum system, properties, and phenomena. An example of quantum spins in fluorescent diamonds is the high-contrast MRI’s and are known as the most advanced quantum systems operating that is used in a real-life environment.
The surface of the nanodiamonds was renovated with polymer structures by the researchers. Then it was injected into the C.elegans nematode worms. It is the most common model used in the experiments of biology. Researchers wanted to learn about the temperature that is healthy for these worms.
When the nanodiamonds were put inside the worms they moved quickly, but the quantum thermometry algorithm got track of them and measured their temperature. The researchers were able to succeed in persuading fever in the C.elegans by appealing their mitochondria with the help of pharmacological treatment and then an increase in temperature was noticed in the worms with the quantum thermometer.
Temperature rise inside C. elegans worms by chemical stimulation.
“Osaka City University’s Masazumi Fujiwara, a lecturer at the university’s Department of Science, said that it was fascinating to see quantum technology work so well in live organisms. He added that he never thought that the temperature of the worm, a size less than 1mm, could deviate from normal and develop into a fever.”
Well, the observation of the research was an important breakthrough that will show the direction ahead for quantum sensing as it devotes more to the analysis and findings of biology.