Study Revealed Turnaround In The Biology of Aging

The basic building formation of living things is formed by cells. Each time the cell in our body clones the youthful part of us breaks into pieces and forms dust. The shortening of telomeres is the main reason behind it.

There are two main biological trademarks of aging –

  • Telomere Length Shortening
  • Accumulation Of Senescent Cells

The latest research by Aviv University and the Sagol Center For Hyperbaric Medicine and Research At Shamir Medical Center revealed that both of the biological trademarks can be reversed. The length of the telomere was increased and the senescent cells were decreased in an aging healthy living body maintaining the protocol of HBOT ( Hyperbaric Oxygen Therapy ). The study is published in the journal Aging. Biological degradation of aging forms the major factor for cancer, cardiovascular diseases, diabetes, dementia, and Alzheimer’s disease.

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In the cellular process, two things form the major factor during the aging process. They are –

  • The decrease in telomere length, of nearly 20-40 bases per year, which is correlated with various serious-illness.
  • The collected amount of the senescent cells forbid cell proliferation. The collection of the senescence adds to many age-related problems and illnesses. Withdrawing those cells can just reverse it which has been observed in animal studies previously.

The testing part of the research program took place in Israel, and it was organized by Prof. Efrati and Amir Hadanny, co-author of the study. The testing took place with 35 healthy adults aged 64 and older who did not go through any lifestyle, diet, or medication modification. Everyone received 60 daily HBOT sessions for 90 days. In the 30th and 60th session and 7 to 14 days before the last HBOT session, whole blood samples were collected to form an opinion on PMBCs (Peripheral blood mononuclear cells).

Prof. Shai Efrati said “After dedicating our HBOT research to exploring its impact on the areas of brain functionality and age-related cognitive decline, we have now uncovered for the first time in humans HBOT’s biological effects at the cellular level in healthy aging adults. Since telomere shortening is considered the ‘Holy Grail’ of the biology of aging, many pharmacological and environmental interventions are being extensively explored in the hopes of enabling telomere elongation. The significant improvement of telomere length shown during and after these unique HBOT protocols provides the scientific community with a new foundation of understanding that aging can, indeed, be targeted and reversed at the basic cellular-biological level.

The results showed that the telomere length of T helper, T cytotoxic, natural killer, and B cells increased significantly, by over 20 percent, following HBOT. B cells had the most compelling change that expanded in the 30th and 60th session and post HBOT by 25.68%±40.42 (p=0.007), 29.39%±23.39 (p=0.0001), and 37.63%±52.73 (p=0.007). Also, there was a decline in the number of senescent T helpers by -37.30%±33.04 post-HBOT (P<0.0001). T-cytotoxic senescent cell percentages decreased compelling by -10.96%±12.59 (p=0.0004) post-HBOT.

Dr. Hadanny illustrated that “Until now, interventions such as lifestyle modifications and intense exercise were shown to have some inhibition effect on the expected telomere length shortening. However, what is remarkable to note in our study, is that in just three months of HBOT, we were able to achieve such significant telomere elongation – at rates far beyond any of the currently available interventions or lifestyle modifications. With this pioneering study, we have opened a door for further research on the prolonged cellular impact of HBOT to reverse the aging process.”

Demonstrating the above results it is clearly visible that this type of amazing research will help to advance the aging process in the upcoming future.

Source – prnewswire

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